Development of a chimeric DNA-RNA hammerhead ribozyme targeting SARS virus.
Identifieur interne : 002B40 ( Main/Exploration ); précédent : 002B39; suivant : 002B41Development of a chimeric DNA-RNA hammerhead ribozyme targeting SARS virus.
Auteurs : Akiko Fukushima [Japon] ; Noboru Fukuda ; Yimu Lai ; Takahiro Ueno ; Mitsuhiko Moriyama ; Fumihiro Taguchi ; Akifumi Iguchi ; Kazushi Shimizu ; Kazumichi KurodaSource :
- Intervirology [ 1423-0100 ] ; 2009.
Descripteurs français
- KwdFr :
- ARN catalytique (génétique), ARN catalytique (pharmacologie), ARN viral (métabolisme), Animaux, Antiviraux (pharmacologie), Données de séquences moléculaires, Lignée cellulaire, Modèles moléculaires, Réplication virale (), Souris, Stabilité de l'ARN, Séquence nucléotidique, Virus de l'hépatite murine (), Virus de l'hépatite murine (génétique), Virus de l'hépatite murine (physiologie), Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (physiologie).
- MESH :
- génétique : ARN catalytique, Virus de l'hépatite murine, Virus du SRAS.
- métabolisme : ARN viral.
- pharmacologie : ARN catalytique, Antiviraux.
- physiologie : Virus de l'hépatite murine, Virus du SRAS.
- Animaux, Données de séquences moléculaires, Lignée cellulaire, Modèles moléculaires, Réplication virale, Souris, Stabilité de l'ARN, Séquence nucléotidique, Virus de l'hépatite murine, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Base Sequence, Cell Line, Mice, Models, Molecular, Molecular Sequence Data, Murine hepatitis virus (drug effects), Murine hepatitis virus (genetics), Murine hepatitis virus (physiology), RNA Stability, RNA, Catalytic (genetics), RNA, Catalytic (pharmacology), RNA, Viral (metabolism), SARS Virus (drug effects), SARS Virus (genetics), SARS Virus (physiology), Virus Replication (drug effects).
- MESH :
- chemical , genetics : RNA, Catalytic.
- chemical , metabolism : RNA, Viral.
- chemical , pharmacology : Antiviral Agents, RNA, Catalytic.
- drug effects : Murine hepatitis virus, SARS Virus, Virus Replication.
- genetics : Murine hepatitis virus, SARS Virus.
- physiology : Murine hepatitis virus, SARS Virus.
- Animals, Base Sequence, Cell Line, Mice, Models, Molecular, Molecular Sequence Data, RNA Stability.
Abstract
Severe acute respiratory syndrome (SARS) is a severe pulmonary infectious disease caused by a novel coronavirus. To develop an effective and specific medicine targeting the SARS-coronavirus (CoV), a chimeric DNA-RNA hammerhead ribozyme was designed and synthesized using a sequence homologous with the mouse hepatitis virus (MHV).
DOI: 10.1159/000215946
PubMed: 19420961
Affiliations:
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Le document en format XML
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Lai</name></author><author><name sortKey="Ueno, Takahiro" sort="Ueno, Takahiro" uniqKey="Ueno T" first="Takahiro" last="Ueno">Takahiro Ueno</name></author><author><name sortKey="Moriyama, Mitsuhiko" sort="Moriyama, Mitsuhiko" uniqKey="Moriyama M" first="Mitsuhiko" last="Moriyama">Mitsuhiko Moriyama</name></author><author><name sortKey="Taguchi, Fumihiro" sort="Taguchi, Fumihiro" uniqKey="Taguchi F" first="Fumihiro" last="Taguchi">Fumihiro Taguchi</name></author><author><name sortKey="Iguchi, Akifumi" sort="Iguchi, Akifumi" uniqKey="Iguchi A" first="Akifumi" last="Iguchi">Akifumi Iguchi</name></author><author><name sortKey="Shimizu, Kazushi" sort="Shimizu, Kazushi" uniqKey="Shimizu K" first="Kazushi" last="Shimizu">Kazushi Shimizu</name></author><author><name sortKey="Kuroda, Kazumichi" sort="Kuroda, Kazumichi" uniqKey="Kuroda K" first="Kazumichi" last="Kuroda">Kazumichi Kuroda</name></author></analytic><series><title level="j">Intervirology</title><idno 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To develop an effective and specific medicine targeting the SARS-coronavirus (CoV), a chimeric DNA-RNA hammerhead ribozyme was designed and synthesized using a sequence homologous with the mouse hepatitis virus (MHV).</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Fukuda, Noboru" sort="Fukuda, Noboru" uniqKey="Fukuda N" first="Noboru" last="Fukuda">Noboru Fukuda</name><name sortKey="Iguchi, Akifumi" sort="Iguchi, Akifumi" uniqKey="Iguchi A" first="Akifumi" last="Iguchi">Akifumi Iguchi</name><name sortKey="Kuroda, Kazumichi" sort="Kuroda, Kazumichi" uniqKey="Kuroda K" first="Kazumichi" last="Kuroda">Kazumichi Kuroda</name><name sortKey="Lai, Yimu" sort="Lai, Yimu" uniqKey="Lai Y" first="Yimu" last="Lai">Yimu Lai</name><name sortKey="Moriyama, Mitsuhiko" sort="Moriyama, Mitsuhiko" uniqKey="Moriyama M" first="Mitsuhiko" last="Moriyama">Mitsuhiko Moriyama</name><name sortKey="Shimizu, Kazushi" sort="Shimizu, Kazushi" uniqKey="Shimizu K" first="Kazushi" last="Shimizu">Kazushi Shimizu</name><name sortKey="Taguchi, Fumihiro" sort="Taguchi, Fumihiro" uniqKey="Taguchi F" first="Fumihiro" last="Taguchi">Fumihiro Taguchi</name><name sortKey="Ueno, Takahiro" sort="Ueno, Takahiro" uniqKey="Ueno T" first="Takahiro" last="Ueno">Takahiro Ueno</name></noCountry><country name="Japon"><region name="Région de Kantō"><name sortKey="Fukushima, Akiko" sort="Fukushima, Akiko" uniqKey="Fukushima A" first="Akiko" last="Fukushima">Akiko Fukushima</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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